Tom Schwarz's Lab

Boston Children's Hospital, F.M. Kirby Neurobiology Center

Schwarz Lab Publications Since 2007

Original Publications:

Pack-Chung, E., Kurshan, P.T., Dickman, D.K., and Schwarz, T.L. (2007) A Drosophila Kinesin Required for Synaptic Bouton Formation and Synaptic Vesicle Transport. Nature Neuroscience 10:980-989.

Dickman, D.K., Kurshan, P.T., and Schwarz, T.L. (2008) Mutations in a Drosophila a2d voltage-gated calcium channel subunit reveal a crucial synaptic function. J. Neurosci. 28:31-38.

Miech, C., Pauer, H.-U., He, X., and Schwarz, T.L. (2008) Presynaptic Local Signaling by a Canonical Wingless Pathway Regulates Development of the Drosophila Neuromuscular Junction. J. Neurosci: 28:10875-84.

Wang, X. and Schwarz, T.L. (2009) The mechanism of Ca ++ regulation of kinesin- mediated mitochondrial motility. Cell 136:163-174.

Wang, X. and Schwarz, T.L. (2009) Imaging axonal transport of mitochondria. Methods in Enzymology. 457:319-333.

Kurshan, P.T., Oztan, A. and Schwarz, T.L. (2009) Presynaptic a2d-3 protein is required for synaptic morphogenesis independent of its Ca ++-channel functions. Nature Neuroscience 12:1411-1419

Graf, E.R., Daniels, R.W., Burgess, R.W., Schwarz ,T.L., DiAntonio, A. (2009) Rab3 dynamically controls protein composition at active zones. Neuron 64:663-77.

Higashi-Kovtun, M.E., Mosca, T.J., Dickman, D.K., Meinertzhagen, I.M., and Schwarz, T.L. (2010). Importin-ß11 regulates synaptic pMAD and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J. Neurosci 30:5253-68.

Murthy, M., Teodoro, R.O., Miller, T.P., and Schwarz, T.L. (2010). Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. Development, 137:2773-83.

Mosca, T.J. and Schwarz, T.L. (2010) The nuclear import of Frizzled2-C by Importins beta11 and alpha2 promotes postsynaptic development. Nat Neurosci. 66:624-7.

Mosca, T.J. and Schwarz, T.L. (2010) Drosophila Importin-a2 is involved in synapse, axon and muscle development. PLoS One 5(12):e15223.

Wang, X., Winter, D., Ashrafi, G., Schlehe, J., Wong, Y.L., Selkoe, D., Rice, S.J., Steen, J., LaVoie, M.J., and Schwarz, T.L. (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893-907

Teodoro, R.O., Pekkurnaz, G., Nasser, A., Higashi-Kovtun, M.E., Balakireva, M., McLachlan, I.G., Camonis, J., Schwarz, T.L. (2013) Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst. EMBO J. 32(14):2039-55.

Pekkurnaz, G.,Trinidad, J.C., Wang, X., Kong, D., Schwarz, T.L. (2014) Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase. Cell 158(1):54-68

Ashrafi, G., Schlehe, J.S., LaVoie, M.J., Schwarz, T.L. (2014) Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. The Journal of Cell Biology 206:655-670.

Ashrafi, G., Schwarz, T.L. (2015) PINK1- and PARK2-mediated local mitophagy in distal neuronal axons. Autophagy 11:187-189.

Chung, J.Y., Steen, J.A., Schwarz, T.L. (2016) Phosphorylation-Induced Motor Shedding Is Required at Mitosis for Proper Distribution and Passive Inheritance of Mitochondria. Cell Reports 16:2142-2155.

Shlevkov, E., Kramer, T., Schapansky, J., LaVoie, M.J., Schwarz, T.L. (2016) Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc. Natl. Acad. Sci. U.S.A. 201612283.

Reviews, Commentaries, and Book Chapters

Schwarz, T.L. (2007) Transmitter release at the neuromuscular junction. Int Rev Neurobiol. 75:105-44.

Glater, E. L. and Schwarz, T. L. Organization and Transport of Mitochondria in Neurons. New Encyclopedia of Neuroscience. Elsevier.

Schwarz, T.L. (2008). Synaptic Transmission. Ch. 8 in Fundamentals of Neuroscience, 3rd edition., L. Squire ed.

Zucker, R.S., Kullmann, D.M., and Schwarz, T.L. (in press). Release of Neurotransmitters. Ch. 8 in From Molecules to Networks, An Introduction to Cellular and Molecular Neuroscience, 2nd edition. Byrne, J.H. and Roberts, J.L. eds.

Goldstein, A.Y., Wang, X, and Schwarz, T.L. (2008). Axonal Transport and the Delivery of Pre-synaptic Components. Curr. Opin. Neurobiol. 18:495-503.

Goldstein, A.Y. and Schwarz, T.L. (2010). Are Presynaptic Proteins Predisposed to Self-Assemble? Neuron 66: 624-627.

Cronin, M.A. and Schwarz, T.L. (2012). The CAP-Gly of p150: One Domain, Two Diseases, and a Function at the End. Neuron 74: 211-213.

Ashrafi, G. and Schwarz, T.L (2013). The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20(1):31-42.

Schwarz, T.L. (2013) Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol. 5(6). pii: a011304.

Gornstein, E., Schwarz, T.L. (2014) The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology 76 Pt A:175-83.

Shlevkov, E., Schwarz, T.L. (2014) Have you seen? For parkin, it's not all or nothing. EMBO J. 18;33(4):277-9.