Tom Schwarz's Lab

Boston Children's Hospital, F.M. Kirby Neurobiology Center

Schwarz Lab Publications Since 2007

Original Publications:

Harbauer, A.B., Hees, J.T., Wanderoy, S., Segura, I., Gibbs,W., Cheng, Y., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., Perocchhi, F., He Z. G., & Schwarz, T. L. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron, 110(9), 1516-1531 (2022)

Cline, H.T., & Schwarz, T. L. Editorial overview: Cellular Nneuroscience. Curr Opin Neurobiol. 63:iii-vi (2020)

Basu, H., & Schwarz, T. L. QuaVadoPro, an autonomous tool for measuring intracellular dynamics using temporal variance. Curr Protoc Cell Biol. 87(1):e108 (2020)

Basu, H., Ding, L., Pekkurnaz, G., Cronin, M., & Schwarz, T. L. Kymolyzer, a semi-autonomous kymography tool to analyze intracellular motility. Curr Protoc Cell Biol. 87(1):e107 (2020)

Shlevkov, E., Basu, H., Bray, M.A., Sun, Z., Wei, W., Apaydin, K., Karhohs, K., Chen, P.F., Smith, J.L.M., Wiskow, O., Roet, K., Huang, X., Eggan, K., Carpenter, A.E., Kleiman, R.J., & Schwarz, T. L. A high-content screen identifies TPP1 and Aurora B as regulators of axonal mitochondrial transport. Cell Rep. 28(12):3224-3237.e5 (2019)

Gutnick, A., Banghart, M. R., West, E. R., & Schwarz, T. L. The light-sensitive dimerizer zapalog reveals distinct modes of immobilization for axonal mitochondria. Nat Cell Biol. (6):768-777 (2019)

Zhao, G., Oztan, A., Ye, Y., & Schwarz, T. L. Kinetochore Proteins Have a Post-Mitotic Function in Neurodevelopment. Developmental Cell, 48(6), 873–882 (2019).

Gornstein, E. L. & Schwarz, T. L. Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects. Exp. Neurol. 288, 153–166 (2017).

Lee, G. & Schwarz, T. L. Filamin, a synaptic organizer in Drosophila, determines glutamate receptor composition and membrane growth. Elife 5, 545 (2016).

Shlevkov, E., Kramer, T., Schapansky, J., LaVoie, M. J. & Schwarz, T. L. Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc. Natl. Acad. Sci. U.S.A. 113, 201612283–E6106 (2016).

Ashrafi, G. & Schwarz, T. L. PINK1- and PARK2-mediated local mitophagy in distal neuronal axons. Autophagy 11, 187–189 (2015).

Ashrafi, G., Schlehe, J. S., LaVoie, M. J. & Schwarz, T. L. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J. Cell Biol. 206, 655–670 (2014).

Pekkurnaz, G., Trinidad, J. C., Wang, X., Kong, D. & Schwarz, T. L. Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell 158, 54–68 (2014).

Schwarz, T. L. Mitochondrial trafficking in neurons. Cold Spring Harbor Perspectives in Biology 5, a011304–a011304 (2013).

Teodoro, R. O. et al. Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst. EMBO J. 32, 2418–2419 (2013).

Wang, X. et al. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147, 893–906 (2011).

Murthy, M., Teodoro, R. O., Miller, T. P. & Schwarz, T. L. Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. Development 137, 2773–2783 (2010).

Higashi-Kovtun, M. E., Mosca, T. J., Dickman, D. K., Meinertzhagen, I. A. & Schwarz, T. L. Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J. Neurosci. 30, 5253–5268 (2010).

Mosca, T. J. & Schwarz, T. L. The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. Nat Neurosci 13, 935–943 (2010).

Mosca, T. J. & Schwarz, T. L. Drosophila Importin-α2 is involved in synapse, axon and muscle development. PLoS ONE 5, e15223 (2010).

Kurshan, P. T., Oztan, A. & Schwarz, T. L. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci 12, 1415–1423 (2009).

Wang, X. & Schwarz, T. L. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell 136, 163–174 (2009).

Goldstein, A. Y., Wang, X. & Schwarz, T. L. Axonal transport and the delivery of pre-synaptic components. Curr. Opin. Neurobiol. 18, 495–503 (2008).

Pack-Chung, E., Kurshan, P. T., Dickman, D. K. & Schwarz, T. L. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci 10, 980–989 (2007).

Reviews, Commentaries, and Book Chapters

Misgeld, T. & Schwarz, T. L. Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture. Neuron 96, 651–666 (2017).

Gornstein, E. & Schwarz, T. L. The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology 76 Pt A, 175–183 (2014).

Shlevkov, E. & Schwarz, T. L. Have you seen? For parkin, it's not all or nothing. EMBO J. 33, 277–279 (2014).

Schwarz, T.L. (2013) Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol. 5(6). pii: a011304.

Ashrafi, G. & Schwarz, T. L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20, 31–42 (2013).

Cronin, M. A. & Schwarz, T. L. The CAP-Gly of p150: one domain, two diseases, and a function at the end. Neuron 74, 211–213 (2012).

Goldstein, A. Y. & Schwarz, T. L. Are presynaptic proteins predisposed to self-assemble? Neuron 66, 624–627 (2010).